Bombax ceiba Linn. leaf extract rich in phenolic compounds to mitigate non-alcoholic fatty liver-related complications in experimental model.
| Autor: | El-Bana, Mona A., Ashour, Magdi N., Rasheed, Wafaa I., Diab, Yasser M., Medhat, Dalia |
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| Předmět: |
INFLAMMATION prevention
PREVENTION of obesity DIABETES prevention BIOLOGICAL models HDL cholesterol TRIGLYCERIDES INTERLEUKINS MEDICINAL plants POLYPHENOLS ANIMAL experimentation LIVER NON-alcoholic fatty liver disease BLOOD sugar LDL cholesterol PEROXISOME proliferator-activated receptors HYPERLIPIDEMIA RATS INSULIN OXIDATIVE stress LEAVES METALLOPROTEINS RESEARCH funding PLANT extracts MITOGEN-activated protein kinases INSULIN resistance LIPIDS CHOLESTEROL ALANINE aminotransferase ASPARTATE aminotransferase DISEASE complications |
| Zdroj: | Journal of Complementary & Integrative Medicine; Jun2023, Vol. 20 Issue 2, p343-352, 10p |
| Abstrakt: | Obesity, diabetes mellitus, insulin resistance (IR), and hypertriglyceridemia are common features observed in non-alcoholic fatty liver diseases (NAFLD). There is a critical medical necessity to find novel therapeutics that can halt the development of NAFLD. Bombax ceiba Linn. leaf extract was prepared and its phytochemical profile was determined. Standard and high carbohydrate high-fat diets (HCHF) were prepared. Rats were fed HCHF for 18 weeks to induce a non-alcoholic fatty liver (NAFL) model. Forty male rats were divided into control, B. ceiba Linn. leaf extract, NAFL, prophylactic, and treated groups. Serum fasting blood sugar (FBS), insulin, insulin resistance (HOMA-IR), cholesterol, high-density lipoprotein (HDL), triglycerides (TG), low density lipoprotein (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), intelectin-1 (ITLN1), p38 MAP kinase (MAPK), peroxisome proliferator-activated receptor alpha (PPAR-α), and interleukin-6 (IL-6) were evaluated. Data obtained showed that HCHF-induced NAFL resulting in a significant increase in FBS, serum insulin, HOMA-IR, cholesterol, LDL, TG, ALT, AST, and IL-6 and a significant decrease in serum levels of HDL, ITLN1, p38 MAP kinase, and PPAR-α compared to the control group. The analysis of B. ceiba Linn. leaf extract showed high content of phenol compounds which may cause a significant decrease in the levels of FBS, insulin, HOMA-IR values, lipid profile, and levels of IL-6 while a significant increase in serum levels of LDL, ITLN1, p38 MAP kinase, and PPAR-α compared to the NAFL group. B. ceiba Linn. Leaf extract is a highly protective and promising therapeutic agent against inflammation and oxidative stress in the NAFLD model induced by HCHF. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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