T cell maturation is significantly affected by SARS‐CoV‐2 infection.

Autor: Walter, Laura Otto, Cardoso, Chandra Chiappin, Santos‐Pirath, Íris Mattos, Costa, Heloisa Zorzi, Gartner, Rafaela, Werle, Isabel, Mohr, Eduarda Talita Bramorski, da Rosa, Julia Salvan, Lubschinski, Tainá Larissa, Felisberto, Mariano, Kretzer, Iara Fabricia, Masukawa, Ivete Ioshiko, Vanny, Patrícia de Almeida, Luiz, Magali Chaves, de Moraes, Ana Carolina Rabello, Dalmarco, Eduardo Monguilhott, Santos‐Silva, Maria Cláudia
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Zdroj: Immunology; Jul2023, Vol. 169 Issue 3, p358-368, 11p
Abstrakt: Coronavirus disease 2019 (COVID‐19) is a respiratory tract infection caused by the new severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). An adequate T cell response is essential not only for fighting disease but also for the creation of immune memory. Thus, the present study aims to evaluate the T cells of patients with moderate, severe and critical COVID‐19 not only at the time of illness but also 2 months after diagnosis to observe whether changes in this compartment persist. In this study, 166 COVID‐19 patients were stratified into moderate/severe and critical disease categories. The maturation and activation of T cells were evaluated through flow cytometry. In addition, Treg cells were analysed. Until 15 days after diagnosis, patients presented a reduction in absolute and relative T lymphocyte counts. After 2 months, in moderate/severe patients, the counts returned to a similar level as that of the control group. In convalescent patients who had a critical illness, absolute T lymphocyte values increased considerably. Patients with active disease did not show differentiation of T cells. Nonetheless, after 2 months, patients with critical COVID‐19 showed a significant increase in CD4+ EMRA (CD45RA+ effector memory) T lymphocytes. Furthermore, COVID‐19 patients showed delayed T cell activation and reduced CD8+ suppressor T cells even 2 months after diagnosis. A reduction in CD4+ Treg cells was also observed, and their numbers returned to a similar level as that of healthy controls in convalescent patients. The results demonstrate that COVID‐19 patients have a delayed activation and differentiation of T cells. In addition, these patients have a great reduction of T cells with a suppressor phenotype. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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