| Autor: |
Charlesworth, J. A., Quin, J. W., MacDonald, G. J., Lennane, R. J., Boughton, C. R. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Nov1978, Vol. 34 Issue 2, p241-247, 7p |
| Abstrakt: |
Serial studies of complement, immunoglobulins, lymphocytotoxins and immune complexes were performed in thirteen patients with uncomplicated infectious mononuclcosis (IM). Two methods were used to detect immune complexes: a Clq-binding assay (Clq-BA) and the Raji-cell radioimmunoassay (RIA). Patients were followed until there was complete serological recovery. Individual complement components were normal or elevated but three patients showed initial reduction in total haemolytic activity. IgG, IgM, and IgA rose moderately during the acute phase. All sera showed thymocyte-specific cytotoxic activity at some time during the acute phase but were negative by 6 months. The Clq-BA was positive initially in twelve patients but had returned to normal by 6 months. The standard Raji RI.A was negative in fifty out of fifty-live samples tested and it is proposed that this reflects the predominant IgM antibody response in these patients. In contrast, incorporation of a muitispecific anti-immunoglobulin into this assay yielded data that was frequently positive; these correlated highly with that of the Clq- B.A (P<0-00l). Lymphocytotoxic activity correlated with the Clq-HA (P<0.001) and the modified Raji RIA (P<0.05). Patterns of lymphocytotoxicity and immune complex reactivity suggested an inverse relationship between these two parameters. It is proposed that this lymphocytotoxicity leads to production of antibody of restricted class permitting enhanced clearance of immune complexes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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