| Abstrakt: |
The toxic effects of systemic thrombolytic doses of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in 36 dogs are summarized. The more important of these are transient hypocoagulability of the blood, transient hypotension, reversible hemoconcentration, reversible liver involvement and variable signs of extravasation at autopsy after sacrifice 24 to 72 hr later. Toxicity was related to the level of induced fibrinolytic activity. To have a predictable thrombolytic effect, CA-7 needed to be administered in doses that were large enough to depress inhibitors sufficiently. Excessive dosage, however, resulted in free proteolysis with often severe toxic manifestations. The subtoxic therapeutic dose range is shown, and the need for control of therapy is discussed. [ABSTRACT FROM AUTHOR] |
