Association Between HTLV-1 Infection and Nasopharyngeal Carcinoma: A Case-control Study.

Autor: Kalantari, Mahmoudreza, Kalantari, Shakiba, Majidi, Mohammad Reza, Baygi, Houshang Rafatpanah, Hosseini, Sare, Javadinia, Seyed Alireza
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Zdroj: Reports of Radiotherapy & Oncology; Dec2021, Vol. 8 Issue 1, p1-3, 3p
Abstrakt: Background: The northeast of Iran is one of the endemic regions of human T-cell lymphotropic virus type-1 (HTLV-1). This study aimed to evaluate the relationship between nasopharyngeal carcinoma and HTLV-1 infection in northeast Iran, an endemic area for HTLV-1. Methods: In this case-control study, paraffin-embedded nasopharyngeal tissue samples of patients with definitive nasopharyngeal carcinoma were evaluated for the presence of the HTLV-1 genome by polymerase chain reaction retrospectively. Results: Thirty patients with nasopharyngeal carcinoma and 30 healthy people were evaluated. All participants were matched in terms of age and gender, and all were living in Mashhad. The HTLV-1 genome was detected in only one of the people in the healthy group. Conclusions: The HTLV-1 infection and nasopharyngeal carcinoma did not correlate significantly. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index