| Autor: |
da Cruz Guedes, Erika, Erustes, Adolfo Garcia, Leão, Anderson H. F. F., Carneiro, César Alves, Abílio, Vanessa C., Zuardi, Antonio W., Hallak, Jaime Eduardo C., Crippa, José Alexandre, Bincoletto, Claudia, Smaili, Soraya S., Reckziegel, Patrícia, Pereira, Gustavo J. S. |
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| Zdroj: |
Neurochemical Research; Aug2023, Vol. 48 Issue 8, p2390-2405, 16p |
| Abstrakt: |
Progressive neurodegenerative disorders such as Parkinson Disease (PD) lack curative or long-term treatments. At the same time, the increase of the worldwide elderly population and, consequently, the extension in the prevalence of age-related diseases have promoted research interest in neurodegenerative disorders. Caenorhabditis elegans is a free-living nematode widely used as an animal model in studies of human diseases. Here we evaluated cannabidiol (CBD) as a possible neuroprotective compound in PD using the C. elegans models exposed to reserpine. Our results demonstrated that CBD reversed the reserpine-induced locomotor alterations and this response was independent of the NPR-19 receptors, an orthologous receptor for central cannabinoid receptor type 1. Morphological alterations of cephalic sensilla (CEP) dopaminergic neurons indicated that CBD also protects neurons from reserpine-induced degeneration. That is, CBD attenuates the reserpine-induced increase of worms with shrunken soma and dendrites loss, increasing the number of worms with intact CEP neurons. Finally, we found that CBD also reduced ROS formation and α-syn protein accumulation in mutant worms. Our findings collectively provide new evidence that CBD acts as neuroprotector in dopaminergic neurons, reducing neurotoxicity and α-syn accumulation highlighting its potential in the treatment of PD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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