Is L-PRF an effective hemostatic agent in single tooth extractions? A cohort study on VKA and DOAC patients.

Autor: Berton, Federico, Costantinides, Fulvia, Stacchi, Claudio, Corradini, Ambra, Di Lenarda, Andrea, Di Lenarda, Roberto
Předmět:
Zdroj: Clinical Oral Investigations; Jun2023, Vol. 27 Issue 6, p2865-2874, 10p, 1 Diagram, 5 Charts
Abstrakt: Objectives: The aim of this clinical observational study was to assess the efficacy of L-PRF as a hemostatic agent in patients under treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). Materials and methods: Patients under oral anticoagulant therapy (VKA or DOACs) who needed a single simple tooth extraction were enrolled. L-PRF plug was positioned inside the alveolus and secured with non-absorbable sutures. Surgical time, pain-VAS, paracetamol intake, intra-operative, post-operative biological complications, and bleeding events have been registered. Results: A total of 112 patients (59 patients for DOAC and 53 for VKA group) were enrolled. Post-operative bleeding was recorded in nine patients (17%) for VKA group and nine patients (15.3%) for DOACs group. None of the patients needed a medical support for managing of bleeding. Seven days after surgery, no cases of post-extractive complications occurred. Conclusions: The use of L-PRF resulted in limited mild late post-operative bleedings without the need of medical intervention. Clinical relevance: The use of L-PRF can be adopted for an uneventful post-operative curse in anticoagulated patients without chasing their therapy for single tooth extraction. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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