GENE EXPRESSION PROFILING OF T(14;18)‐NEGATIVE CD23+ FOLLICLE CENTER LYMPHOMA DEMONSTRATES ACTIVATION OF THE IL4/JAK/STAT6 PATHWAY AND A ROLE IN ITS PATHOGENESIS.

Autor:	Schade, T., Nann, D., Rau, A., Chott, A., Leoncini, L., Fend, F., Salaverria, I., Campo, E., Jaffe, E., Bonzheim, I., Quintanilla‐Martinez de Fend, L.
Předmět:	GENE expression profiling B cell differentiation LYMPHOMAS
Zdroj:	Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p111-112, 2p
Abstrakt:	GENE EXPRESSION PROFILING OF T(14;18)-NEGATIVE CD23+ FOLLICLE CENTER LYMPHOMA DEMONSTRATES ACTIVATION OF THE IL4/JAK/STAT6 PATHWAY AND A ROLE IN ITS PATHOGENESIS B Introduction: b I t i (14;18)-neg FL cases show similar copy number alterations and mutations as carried by I t i (14;18)-pos FL, but with different frequencies. The consequences of I STAT6 i mutations in I t i (14;18)-neg FL have not been investigated, and the impact of STAT6 pathway activation on the tumor microenvironment, which plays a central role in FL, are largely unknown. [Extracted from the article]
Databáze:	Complementary Index
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