IMPROVED EFFICACY AND SAFETY OF ZANUBRUTINIB VERSUS IBRUTINIB IN PATIENTS WITH RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (R/R CLL) IN CHINA: A SUBGROUP OF ALPINE.

Autor: Qiu, L., Zhou, K., Wang, T., Pan, L., Xu, W., Jin, J., Zhang, W., Hu, Y., Hu, J., Feng, R., Li, P., Liu, Z., Liu, P., Jing, H., Gao, S., Yu, K., Wang, Z., Zhang, H., Zhu, X., Sun, Z.
Předmět:
Zdroj: Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p740-742, 3p
Abstrakt: B Introduction: b Zanubrutinib is an irreversible, potent, next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy and minimize off-target inhibition. A favorable safety profile was also observed in pts from China with zanubrutinib compared with ibrutinib, with lower rates of treatment discontinuations and serious AEs in patients with R/R CLL/SLL. [Extracted from the article]
Databáze: Complementary Index