| Autor: |
Bal, E., Corinaldesi, C., Holmes, A. B, Pasqualucci, L., Basso, K., Dalla‐Favera, R. |
| Předmět: |
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| Zdroj: |
Hematological Oncology; Jun2023 Supplement S2, Vol. 41, p89-90, 2p |
| Abstrakt: |
B Introduction: b Subclassifications of Diffuse large B-cell lymphoma (DLBCL) based on genetic alterations has led to the identification of affected genes/pathways, as well as subtypes with prognostic and therapeutic significance. The I NR3C1 i gene encodes a glucocorticoid-activated transcription factor/receptor which we found expressed and active in the nucleus of normal GC B cells. However, these efforts have been largely based on coding genes, while we have recently reported that functionally relevant non-coding regulatory elements of the DLBCL genome, that is, super-enhancers (SEs) are highly and specifically hypermutated in >90% of DLBCL samples (Bal et al. I Nature i 2022). [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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