| Autor: |
Steemers, A., de Kanter, J., Groenen, N., Gonzalez, D. Montiel, Verheul, M., Trabut, L., Meyer‐Wentrup, F., van Boxtel, R. |
| Předmět: |
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| Zdroj: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p603-604, 2p |
| Abstrakt: |
The genetic hallmark of BL is the translocation of the MYC oncogene under the regulation of an immunoglobulin (IG) heavy or light chain enhancer, resulting in MYC protein overexpression. B Results: b From a bone marrow sample of a 4-year-old female BL patient we found that 1% of immune cells were CD10+ B cells, while 17% of B cells were negative for the CD10 marker (Figure 2A). BL can be divided epidemiologically but also, more recently, genetically based on driver mutations including DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3 and CCND3), and Q53-BL (quiet TP53). [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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