An open‐label phase 1/2 study of favezelimab plus pembrolizumab in patients with relapsed/refractory classical Hodgkin lymphoma with/without previous anti‐PD‐1 treatment.

Autor: Lavie, D., Johnson, N., Borchmann, P., Herrera, A. F., Avigdor, A., Gasiorowski, R., Gregory, G., Keane, C., Vucinic, V., Bazargan, M., Herishanu, Y., Minuk, L., Tzoran, I., Andreadis, C., Armand, P., Kuruvilla, J., Zinzani, P. L., West, R. Marceau, Pillai, P., Marinello, P.
Předmět:
Zdroj: Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p364-366, 3p
Abstrakt: B Introduction: b Dual blockade of PD-1 and lymphocyte-activation gene (LAG-3) has shown antitumor activity; however, the activity of the combination for patients (pts) with relapsed or refractory (R/R) classical Hodgkin's lymphoma (cHL) is unclear. An open-label phase 1/2 study of favezelimab plus pembrolizumab in patients with relapsed/refractory classical Hodgkin lymphoma with/without previous anti-PD-1 treatment Pts in cohort 1 had no prior anti-PD-1 therapy; pts in cohort 2 had progression within 12 weeks after >=2 doses of anti-PD-1 therapy, per Cheson 2007 criteria. [Extracted from the article]
Databáze: Complementary Index