Evaluation of ctDNA in a phase I/II trial in relapsed or refractory large B‐cell lymphoma of epcoritamab, a novel, subcutaneous CD3xCD20 bispecific T‐cell–engaging antibody.

Autor: Soong, D., Thieblemont, C., Karavitis, J., Hess, B., Caimi, P., Feldman, T., Hutchings, M., Sureda, A., Szafer‐Glusman, E., Sacchi, M., Jure‐Kunkel, M., Adya, N., Chiu, C.
Předmět:
Zdroj: Hematological Oncology; Jun2023 Supplement S2, Vol. 41, p326-328, 3p
Abstrakt: In patients who responded to epcoritamab, ctDNA levels decreased rapidly, with the majority of patients achieving CR having a deep ctDNA response by C3D1. B Results: b ctDNA quantification was concordant between the assays when within the dynamic range of the clonoSEQ assay (>80% in paired samples tested); however, a greater sensitivity of the AVENIO assay was observed, allowing further exploratory analyses of ctDNA using this platform. B Introduction: b The emergence of novel, more potent therapeutics in the treatment of patients with large B-cell lymphoma (LBCL) has resulted in higher rates of responses and highlighted a need for additional methods, such as minimal residual disease (MRD), to determine the depth and quality of response and potentially guide duration of treatment. [Extracted from the article]
Databáze: Complementary Index