| Autor: |
Gava, F., Faria, C., Gravelle, P., Garcia‐Valero, J., Quelen, C., Serrat, N., Gower, N., Morschhauser, F., Fournié, J., Bouquet, F., Fonseca, C., Herter, S., Codarri, L., McCord, R., Chiang, E., Laurent, C., Perez‐Galan, P., Ysebaert, L., Bezombes, C. |
| Předmět: |
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| Zdroj: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p286-287, 2p |
| Abstrakt: |
Relapsed/refractory B-cell NHLs are made up with a heterogeneous array of incurable diseases, whose outcomes in the rituximab era are unclear, despite patients benefit from new therapeutic strategies. Here, we present a new preclinical follicular lymphoma (FL) 3D model called Patient-Derived Lymphoma Spheroid (FL-PDLS) that recapitulates the FL pathogenesis and the B cells-immune tumor microenvironment crosstalk. This system can evolve towards full FL-TME reconstituted organoids and therefore become powerful theragnostic biomaterials that combine therapy with diagnosis necessary for individualized therapies for patients. [Extracted from the article] |
| Databáze: |
Complementary Index |
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