Gene expression and spatial transcriptomic analysis of paired diagnosis and relapse DLBCL biopsies show a reduction in T cell infiltration and function at relapse.

Autor:	Swain, F., Burgess, M., Kempe, S., Sabdia, M., Wight, J., Hawkes, E., Mutsando, H., Talaulikar, D., Merida de Long, L., Hawula, Z., Birch, S., Wyche, P., Gandhi, M. K., Keane, C.
Předmět:	T cells GENE expression CELL physiology DIFFUSE large B-cell lymphomas TRANSCRIPTOMES
Zdroj:	Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p278-279, 2p
Abstrakt:	B Conclusions: b Key differences in the TME are evident in DLBCL across treatment timepoints with reduced T cell infiltration and function at relapse demonstrated by immune gene expression and spatial transcriptome analysis. B Introduction: b Patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) continue to have poor outcomes despite introduction of innovative immune based therapies. [Extracted from the article]
Databáze:	Complementary Index
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