| Autor: |
Schroers‐Martin, J. G., Kastenschmidt, J., Sworder, B. J., Diehn, M., Wagar, L., Alizadeh, A. A. |
| Předmět: |
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| Zdroj: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p230-230, 1p |
| Abstrakt: |
We therefore developed a robust patient-derived lymphoma organoid (PDLO) system utilizing primary biopsies from FL patients and assessed response to bispecific T-cell mediated immunotherapy. Novel immunotherapies including bispecific T-cell engagers require an intact TME for immune effector function and cannot be modeled in traditional B-cell monocultures. B Conclusions: b FL PDLOs allow ex vivo modeling of T-cell mediated immunotherapies with B-cell killing, activated T-cell expansion, and T-cell exhaustion signatures. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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