[ 18 F]FES PET Resolves the Diagnostic Dilemma of COVID-19-Vaccine-Associated Hypermetabolic Lymphadenopathy in ER-Positive Breast Cancer.

Autor: Nogami, Munenobu, Tsujikawa, Tetsuya, Maeda, Hiroyuki, Kosaka, Nobuyuki, Takahashi, Mizuho, Kinoshita, Naoki, Mori, Tetsuya, Makino, Akira, Kiyono, Yasushi, Murakami, Takamichi, Goi, Takanori, Okazawa, Hidehiko
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Zdroj: Diagnostics (2075-4418); Jun2023, Vol. 13 Issue 11, p1851, 8p
Abstrakt: Coronavirus disease (COVID-19) vaccination is known to cause a diagnostic dilemma due to false-positive findings on [18F]FDG PET in vaccine-associated hypermetabolic lymphadenopathy. We present two case reports of women with estrogen-receptor (ER)-positive cancer of the breast who were vaccinated for COVID-19 in the deltoid muscle. [18F]FDG positron emission tomography (PET) demonstrated primary breast cancer and multiple axillary lymph nodes with increased [18F]FDG uptake, diagnosed as vaccine-associated [18F]FDG-avid lymph nodes. Subsequent [18F]FES PET revealed single axillary lymph node metastasis in the vaccine-associated [18F]FDG-avid lymph nodes. To the best of our knowledge, this is the first study showing the usefulness of [18F]FES PET in diagnosing axillary lymph node metastasis in COVID-19-vaccinated patients harboring ER-positive breast cancer. Thus, [18F]FES PET has potential applications in the detection of true-positive metastatic lymph nodes in patients with ER-positive breast cancer regardless of the ipsilateral or contralateral side, who have received COVID-19 vaccination. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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