| Abstrakt: |
"The present disclosure provides a multispecific binding moiety comprising a PD-1 binding domain and a TGF-bRII binding domain, wherein the PD-1 binding domain blocks PD-1 mediated signaling and the TGF-bRII binding domain blocks TGF-bRII-mediated signaling. A multispecific binding moiety comprising a PD-1 binding domain and a TGF-bRII binding domain, wherein the PD-1 binding domain blocks PD-1 mediated signaling and the TGF-bRII binding domain blocks TGF-bRII-mediated signaling. "The present disclosure also provides a multispecific binding moiety comprising a PD-1 binding domain and a TGF-bRII binding domain, wherein the TGF-bRII binding domain comprises a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences as described further herein. [Extracted from the article] |
