| Autor: |
Kalang, J. J., Hassan, A. Z., Fatihu, M. Y., Avasi, D. O., Gideon, A. O., Tanko, P. N. |
| Předmět: |
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| Zdroj: |
Savannah Veterinary Journal; 2022, Vol. 5 Issue 2, p13-24, 12p |
| Abstrakt: |
Introduction: Wound healing is a delicate process involving myriad of inflammatory reactions. Drugs influencing inflammatory response would logically modulate wound healing. How methylprednisolone, dexamethasone and hydrocortisone may influence wound healing in dogs is not known. This study aimed at histological evaluation of the effects of methylprednisolone, dexamethasone and hydrocortisone effects on wound healing in Nigerian indigenous dogs. Methods: Twelve dogs between ages 12-18 months of both sexes, weighing between 10-18 kg were randomly divided into four groups of 3 dogs each. Following aseptic procedures, the animals were placed on sternal recumbency, pre-anaesthetised with atropine sulphate (0.02mg/kg) and chlorpromazine hydrochloride (0.5mg/kg) intravascularly. The dogs were anaesthetised with thiopentone sodium at 25mg/kg. Using a sterilised wound template, an indelible marker was used to mark a 2 x 3 cm area on the dorsum of the experimental dogs. The dogs in the control group (group 1) were not given any medication. Group 2 were given hydrocortisone at 1mg/kg body weight intramuscularly. Group 3 were given dexamethasone at 0.5mg/kg intramuscularly and group 4 were given methylprednisolone at 1mg/kg intramuscularly as a single dose. Skin biopsies were taken on days 3, 14, 21, and after healing for histopathological evaluation. Results: Amazingly, Methylprednisolone produced not only the best arrangement of collagen but it also induced early epithelisation and thin scar. Significance: The use of steroids in controlling inflammatory processes during surgical procedure does not only influence the healing process, but also positively improve on the scar tissue, depending on the steroid and what the surgeon aims to achieve. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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