| Abstrakt: |
The ubiquitous endocrine condition known as the polycystic ovarian syndrome (PCOS) has an effect on the health of many women around the world. Since the specific aetiology is unknown, the diagnostic criteria are currently insufficient, which contributes to the underdiagnosis and under treatment of PCOS in many women. Eighteen adult Parkes strain mice (age: 4–5 weeks) having a body weight of 18–21 g were separated into three groups at random with 6 animals each as follows: group I, serving the control, received water and a normal chow diet for 45 days; group II received oral gavage administration of letrozole (LETZ) (6 mg/kg bw) which was dissolved in 0.9% NaCl solution for 21 days for the induction of PCOS; group III received oral gavage administration of LETZ (6 mg/kg) for 3 weeks followed by the administration of quercetin (QUER) (125 mg/kg bw orally daily) for 45 days. In our study, we observed that mice with PCOS had increased body weight, ovary mass, blood glucose, cholesterol, low-density lipoprotein (LDL), tumour necrosis factor (TNF-ɑ) and interleukin-6 (IL-6) as well as an increase in testosterone and luteinising hormone (LH). We observed a decline in oestrogen and follicle-stimulating hormone (FSH) and decreased antioxidant capacity in the ovary. These alterations were linked to decreased adiponectin in mice. However, after the QUER administration, these changes were reversed. The results from our study suggested that adiponectin has a direct impact on endocrine and metabolic aspects in PCOS, and its drop can cause women infertility. Therefore, boosting the circulation of adiponectin may be employed as a remedy for metabolic and endocrine conditions in polycystic ovarian syndrome-affected individuals. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink