| Autor: |
Sagastagoitia-Fornie, Marta, Morán-Fernández, Laura, Blázquez-Bermejo, Zorba, Díaz-Molina, Beatriz, Gómez-Bueno, Manuel, Almenar-Bonet, Luis, López-Granados, Amador, González-Vílchez, Francisco, Mirabet-Pérez, Sonia, García-Romero, Elena, Sobrino-Márquez, Jose M., Gregorio Rábago, Juan-Aracil, Castel-Lavilla, Maria Angels, Blasco-Peiro, Teresa, Garrido-Bravo, Iris, De La Fuente-Galán, Luis, Muñiz, Javier, Crespo-Leiro, María G. |
| Předmět: |
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| Zdroj: |
Transplant International; 5/19/2023, Vol. 36, p1-8, 8p |
| Abstrakt: |
In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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