Inflammatory Biomarkers for Early Detection of Leakage Post Graham's Patch Repair of Perforated Peptic Ulcer.

Autor: Refaat, Ahmed, Abosayed, Amir k., Shafik, Ismail, Mashhour, Abdrabou N., El Kady, Moamen, Yahia, Ahmed
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Zdroj: Surgical Chronicles; Jan-Mar2023, Vol. 28 Issue 1, p27-31, 5p
Abstrakt: Purpose: This study aims at detecting the leakage post Graham's patch repair of perforated peptic ulcer using inflammatory biomarkers (ESR, CRP and neutrophil lymphocyte ratio [N/L]) pre-operatively and day 2, 5 postoperatively. Methods: A prospective cohort study was performed at Cairo University's Kasr Al-Ainy Emergency Department. The study comprised 75 patients who presented to the emergency room with a perforated peptic ulcer. The research lasted for six months. Results: On the second postoperative day, the N/L ratio was higher in patients with leakage than in those without leakage, but the difference was not statistically significant. On the fifth postoperative day, the N/L ratio was statistically higher in patients with leakage than in those without leakage, with a significant increase in C-reactive protein (CRP). On day 2, there was no difference in ESR levels between patients with leakage and those without leakage. On day 5, there was an increase, but it was not statistically significant. Conclusion: It is possible to detect early leakage after Graham's patch repair of a perforated peptic ulcer by monitoring CRP and NLR levels. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index