| Autor: |
Gupta, Suman, Saning, Amonrada, Laodheerasiri, Sireerat, Chuenchom, Laemthong, Watcharin, Waralee |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2023, Vol. 2720 Issue 1, p1-7, 7p |
| Abstrakt: |
The use of essential oils (EO) with many biological activities has become attractive in various fields of science. Grapefruits (C. paradisi) are known for their high antioxidant and anti-inflammatory properties attributed to their flavonoid content. However, the use of grapefruit oil in pharmaceutical and cosmetic products has been limited by its effectiveness and stability as it is sensitive to oxygen, heat, moisture and light. To improve its bioactivity and increase the stability, nanoencapsulation of grapefruit essential oil and carrageenan has been developed. Nanoencapsulated grapefruit essential oil with carrageenan was prepared by o/w single emulsion solvent evaporation method at grapefruit essential oil concentration of 0.5% w/v. The pH, density, total solid content, and particle size and morphology of nanoencapsulated grapefruit essential oil were observed for physical characteristics and its stability. The cytotoxicity of the nanoencapsulated grapefruit essential oil was also evaluated. The prepared particles appeared as a visibly cloudy emulsion demonstrating no sign of instability through phase separation. An average diameter size of nanoencapsulated particles was smaller than 100 nm and a zeta potential was in the range of-20 to-40 mV. The scanning electron microscopy results confirmed that nanoencapsulated grapefruit essential oil was spherical in shape. The cytotoxicity evaluation indicated that nanoencapsulated grapefruit essential oil showed over 80% and 90% of cell viability against HT29and MCF7 cell lines suggesting these nanoencapsulated particles were non-toxic and may lead to have potential pharmaceutical applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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