| Autor: |
Al-Majedy, Yasameen K., Ibraheem, Hiba H., Issa, Ali Abdullah |
| Předmět: |
|
| Zdroj: |
AIP Conference Proceedings; 2023, Vol. 2593 Issue 1, p1-16, 16p |
| Abstrakt: |
The purpose of this study was to synthesize coumarins, which have a structurally interesting antioxidant function. To produce target molecules, several reaction pathways were used to modify 7-hydroxycoumarin. Different spectroscopical approaches were used to characterize molecular structures (Fourier transformation infrared and nuclear magnetic resonance). Various in vitro spectrophometric tests against the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydrogen peroxide were used to assess antioxidant activity (H2O2). When compared to ascorbic acid, all substances performed well as antioxidants. Compound 4 had the highest efficiency scavenging activity (90.0 ±3.0), followed by compounds 3 and 2 (87.05 ±.00; and 86.0 ±2.00). The standard medication was ascorbic acid C, which had 91.00 ±1.5 of a percentage inhibition. The antioxidant mechanisms of the produced compounds were also investigated. Since the newly synthesized derivatives contain a variety of functional groups and may be microbiologically active. As a result, we examined the microbiological function of these derivatives in a variety of bacteria and fungi species. In terms of microorganism growth inhibition, the compounds tested showed varying levels of activity. Antibacterial properties have been discovered in newly synthesized derivatives. The synthesized coumarins were determined DFT using molecular structures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
