Healthcare-Associated Respiratory Syncytial Virus in Children's Hospitals.
Autor: | Saiman, Lisa, Coffin, Susan E, Kociolek, Larry K, Zerr, Danielle M, Milstone, Aaron M, Aldrich, Margaret L, Vargas, Celibell Y, Zapata, Giovanny, Zalot, Morgan A, Reyna, Megan E, Adler, Amanda, Voskertchian, Annie, Egbert, Emily R, Alba, Luis, Gollerkeri, Sonia, Ruggieri, Madelyn, Finelli, Lyn, Choi, Yoonyoung |
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Předmět: |
PUBLIC health surveillance
RESEARCH CONFIDENCE intervals CHILDREN'S hospitals MULTIVARIATE analysis TIME CROSS infection RETROSPECTIVE studies ACQUISITION of data TREATMENT effectiveness MEDICAL records DESCRIPTIVE statistics RESEARCH funding RESPIRATORY syncytial virus infections ODDS ratio COMORBIDITY |
Zdroj: | Journal of the Pediatric Infectious Diseases Society; May2023, Vol. 12 Issue 5, p265-272, 8p |
Abstrakt: | Background Outbreaks of healthcare-associated respiratory syncytial virus (HA-RSV) infections in children are well described, but less is known about sporadic HA-RSV infections. We assessed the epidemiology and clinical outcomes associated with sporadic HA-RSV infections. Methods We retrospectively identified hospitalized children ≤18 years old with HA-RSV infections in six children's hospitals in the United States during the respiratory viral seasons October–April in 2016–2017, 2017–2018, and 2018–2019 and prospectively from October 2020 through November 2021. We evaluated outcomes temporally associated with HA-RSV infections including escalation of respiratory support, transfer to the pediatric intensive care unit (PICU), and in-hospital mortality. We assessed demographic characteristics and comorbid conditions associated with escalation of respiratory support. Results We identified 122 children (median age 16.0 months [IQR 6, 60 months]) with HA-RSV. The median onset of HA-RSV infections was hospital day 14 (IQR 7, 34 days). Overall, 78 (63.9%) children had two or more comorbid conditions; cardiovascular, gastrointestinal, neurologic/neuromuscular, respiratory, and premature/ neonatal comorbidities were most common. Fifty-five (45.1%) children required escalation of respiratory support and 18 (14.8%) were transferred to the PICU. Five (4.1%) died during hospitalization. In the multivariable analysis, respiratory comorbidities (aOR: 3.36 [CI |
Databáze: | Complementary Index |
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