| Autor: |
Liao, Wenjing, Chen, Gui, Song, Lijuan, Xu, Meiqian, Li, Hao, Wang, Yiyan, Wang, Xiaofen, Ye, Jinfeng, Ren, Mei, Kuang, Xiaoxuan, Tang, Yaqiang, Yang, Saixuan, Ning, Xiaoping, Xie, Jianlei, Yang, Zhaowei, Zhang, Xiaowen |
| Předmět: |
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| Zdroj: |
Allergy; Jun2023, Vol. 78 Issue 6, p1707-1710, 4p |
| Abstrakt: |
Temperature change affects human health and asthma.[[1]] Serum IgE concentrations were shown to be significantly lower in experimental asthmatic mice treated at thermoneutral (30°C) than those treated at standard housing temperature (20°C).[3] A recent study found that the exosomes of mast cells (MC) can compete with MC to bind serum IgE and reduce asthma symptoms.[4] This study aimed to investigate whether temperature directly affects MC-derived exosomes in mediating the high-affinity receptor for IgE (Fc RI)-dependent MC activation and ovalbumin-induced asthma. In summary, this study provides evidence of the temperature-dependent regulation of MC-derived exosomes through regulation of Rab3a expression, which protected against Fc RI-dependent MC activation in vitro and experimental asthma in vivo. Temperature regulates Rab3a and mast cell-derived exosomal Fc RI to inhibit mast cell activation. [Extracted from the article] |
| Databáze: |
Complementary Index |
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