| Autor: |
Tan, Karen M. L., Chee, Jolene, Lim, Kezlyn L. M., Ng, Maisie, Gong, Min, Xu, Jia, Tin, Felicia, Natarajan, Padmapriya, Lee, Bee Lan, Ong, Choon Nam, Tint, Mya Thway, Kee, Michelle Z. L., Müller-Riemenschneider, Falk, Gluckman, Peter D., Meaney, Michael J., Kumar, Mukkesh, Karnani, Neerja, Eriksson, Johan G., Nandanan, Bindu, Wyss, Adrian |
| Zdroj: |
Nutrients; May2023, Vol. 15 Issue 10, p2325, 18p |
| Abstrakt: |
Background: β-cryptoxanthin is a dietary carotenoid for which there have been few studies on the safety and pharmacokinetics following daily oral supplementation. Methods: 90 healthy Asian women between 21 and 35 years were randomized into three groups: 3 and 6 mg/day oral β-cryptoxanthin, and placebo. At 2, 4, and 8 weeks of supplementation, plasma carotenoid levels were measured. The effects of β-cryptoxanthin on blood retinoid-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition were investigated. Results: β-cryptoxanthin supplementation for 8 weeks (3 and 6 mg/day) was found to be safe and well tolerated. Plasma β-cryptoxanthin concentration was significantly higher in the 6 mg/day group (9.0 ± 4.1 µmol/L) compared to 3 mg/day group (6.0 ± 2.6 µmol/L) (p < 0.03), and placebo (0.4 ± 0.1 µmol/L) (p < 0.001) after 8 weeks. Plasma all-trans retinol, α-cryptoxanthin, α-carotene, β-carotene, lycopene, lutein, and zeaxanthin levels were not significantly changed. No effects were found on blood retinol-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition. Conclusions: Oral β-cryptoxanthin supplementation over 8 weeks lead to high plasma concentrations of β-cryptoxanthin, with no impact on other carotenoids, and was well tolerated in healthy women. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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