Limosilactobacillus fermentum Strains with Claimed Probiotic Properties Exert Anti-oxidant and Anti-inflammatory Properties and Prevent Cardiometabolic Disorder in Female Rats Fed a High-Fat Diet.

Autor: de Luna Freire, Micaelle Oliveira, do Nascimento, Luciana Caroline Paulino, de Oliveira, Kataryne Árabe Rimá, de Oliveira, Alisson Macário, dos Santos Lima, Marcos, Napoleão, Thiago Henrique, da Costa Silva, João Henrique, Lagranha, Cláudia Jacques, de Souza, Evandro Leite, de Brito Alves, José Luiz
Zdroj: Probiotics & Antimicrobial Proteins; Jun2023, Vol. 15 Issue 3, p601-613, 13p
Abstrakt: This study assessed the effects of a mixed formulation containing Limosilactobacillus (L.) fermentum 139, L. fermentum 263, and L. fermentum 296 on cardiometabolic parameters, inflammatory markers, short-chain fatty acid (SCFA) fecal contents, and oxidative stress in colon, liver, heart, and kidney tissues of female rats fed a high-fat diet (HFD). Female Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6). L. fermentum formulation (1 × 109 CFU/mL of each strain) was administered two twice a day for 4 weeks. Administration of L. fermentum increased acetate and succinate fecal contents and reduced hyperlipidemia and hyperglycemia in rats fed a HFD (p < 0.05). Administration of L. fermentum decreased low-grade inflammation and improved antioxidant capacity along the gut, liver, heart, and kidney tissues in female rats fed a HFD (p < 0.05). Administration of L. fermentum prevented dyslipidemia, inflammation, and oxidative stress in colon, liver, heart, and kidney in female rats fed a HFD. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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