| Autor: |
Shuvaev, Alexander D., Zhilin, Egor S., Fershtat, Leonid L. |
| Předmět: |
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| Zdroj: |
Synthesis; Jun2023, Vol. 55 Issue 12, p1863-1874, 12p |
| Abstrakt: |
A direct approach toward the construction of furoxan-sydnone imine double NO-donors involving the NOBF4-mediated nitrosation–cyclization sequence of α-amino nitriles as a key synthetic step was developed. The described protocol excludes the isolation of carcinogenic N -nitrosamines, operates broad substrate scope, and enables the preparation of fully substituted sydnone imines linked to the furoxan ring via different linkers or directly through C–C bond. Synthesized library of furoxan-sydnone imine hybrids demonstrated a promising ability to release NO in a wide range of concentrations which is useful for various biomedical insights. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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