| Autor: |
Wenbin XU, Yimeng GAO, Nailong LLANG, Ling ZHANG, Shuang XING, Wensong HAO, Shaoeong LI |
| Předmět: |
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| Zdroj: |
Medicinal Plant; Apr2023, Vol. 14 Issue 2, p57-62, 6p |
| Abstrakt: |
[Objectives] To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment. [Methods] The effects of propolis on inflammation, and proliferation were analyzed based on the levels of DNA transcriptional regulation and mRNA and protein expression levels. [Results] Propolis water extract (PWE) could inhibit the cell proliferation and production of DNA damage in a dosedependent manner. Moreover, the propolis water extract could significantly downregulate the expression of iNOS-Luc, PTGS-2-Luc, and lL-8-Luc, and that it was related to the expression of the NF-kB family protein. After the induction of HeLa cells by propolis, the expression of the cell cycle inhibitor gene p21 was increased, while that of the cell proliferation gene Ki67 was decreased. [Conclusions] Propolis water extract could significantly inhibit the cell proliferation and production of DNA damage, suggesting propolis as a potential candidate for the development of adjunctive therapy against cervical cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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