| Autor: |
Elesh, Heba M., Kotb, Dina A., Zaghloul, Khalid H., Abdellateif, Abd-El-karim M., Tawfik, Wessam S. |
| Předmět: |
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| Zdroj: |
Egyptian Academic Journal of Biological Sciences. D, Histology & Histochemistry; Jun2023, Vol. 15 Issue 1, p79-99, 21p |
| Abstrakt: |
Sodium nitrite (NaNO2) is a main colorant and food preservative in the food industry. Besides the variety of medicinal and industrial applications, toxicity for animals and humans is well documented after overexposure of nitrite. This study aimed to investigate the reproductive toxicity of sodium nitrite and its modulation by ascorbic acid as an antioxidant in male mice. 60 adult male albino mice were used and divided into (6) groups. Gp(I) control. Gp(II) administered 100 mg/kg/d of ascorbic acid. Gp(III & IV) were received (16 and 32 mg/kg/day) sodium nitrite. Gp(V and VI) received (16 and 32 mg/kg/d) NaNO2 and 100 mg/kg/d of ascorbic acid. Male mice were orally administered NaNO2 by gastric intubation for 35 days. The study demonstrated that ascorbic acid ameliorates the alterations induced by sodium nitrite in reproductive performance, gonadosomatic index, testicular weight, sperm morphology, motility and count and repairing in the recorded histopathological lesions in the testis tissues. It could be concluded that ascorbic acid treatment has ameliorative effects against sodium nitrite reproductive toxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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