Metabolic Analysis of Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms (MTHFR 677C
Autor:
Hassan, Mohammed H., Raslan, Mohamed A., Tharwat, Mena, Sakhr, Hala M., El-Khateeb, Eslam El-Sayed, Sakr, Shimaa Fathy, Ameen, Hesham H., Hamdan, Ali R.
Zdroj:
Indian Journal of Clinical Biochemistry; Jul2023, Vol. 38 Issue 3, p305-315, 11p
Abstrakt:
Neural tube defects (NTDs) are among the most prevalent and debilitating birth defects with their causes are still unknown, despite mounting evidence that genetic and/or environmental factors may play a role. We aimed to analyze two single nucleotide polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene, serum folate and vitamin B12 status among a cohort of Egyptian children with NTDs and their mothers. A case–control study has been conducted on 50 Egyptian children with various types of NTDs and their mothers. They were comparable with 50 unrelated healthy, age and sex matched children and their mothers (50) selected as controls. Pediatric and neurosurgical assessments were performed to the included cases. Serum folate and vitamin B12 were measured using ELISA kits. MTHFR 677C
Databáze:
Complementary Index
Externí odkaz:
| Autor: | Hassan, Mohammed H., Raslan, Mohamed A., Tharwat, Mena, Sakhr, Hala M., El-Khateeb, Eslam El-Sayed, Sakr, Shimaa Fathy, Ameen, Hesham H., Hamdan, Ali R. |
|---|---|
| Zdroj: | Indian Journal of Clinical Biochemistry; Jul2023, Vol. 38 Issue 3, p305-315, 11p |
| Abstrakt: | Neural tube defects (NTDs) are among the most prevalent and debilitating birth defects with their causes are still unknown, despite mounting evidence that genetic and/or environmental factors may play a role. We aimed to analyze two single nucleotide polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene, serum folate and vitamin B12 status among a cohort of Egyptian children with NTDs and their mothers. A case–control study has been conducted on 50 Egyptian children with various types of NTDs and their mothers. They were comparable with 50 unrelated healthy, age and sex matched children and their mothers (50) selected as controls. Pediatric and neurosurgical assessments were performed to the included cases. Serum folate and vitamin B12 were measured using ELISA kits. MTHFR 677C |
| Databáze: | Complementary Index |
| Externí odkaz: |
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