| Autor: |
Bhagat, Arti, Kumar Reddy, Bandakadi Sandeep, Rudra, Pranathi, Raina, Drove Jee |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 4, p1682-1690, 9p |
| Abstrakt: |
Background: Reduction of proteinuria as a targeted strategy in subjects with advanced chronic renal disease is proven to be effective in the current scenario. However, the evidence is lacking owing to lesser available literature data. Aim: The present study aimed to assess the efficacy of proteinuria as a treatment target in subjects with chronic kidney disease. Methods: The study assessed 946 subjects having pre-end stage renal disease suggested by baseline GFR <45ml/min/1.73m2 that were assessed for the effect of proteinuria change on renal death (death before dialysis initiation and a composite of dialysis). Results: For predictors related to annual GFR change in study subjects, the mean of herbal medicine use was -1.51±0.64 with p=0.01, BMI (<-0.4 or >2.4 kg/m2) was 0.64±0.25 with p=0.006, non-diabetes and the non-RAS blockade was 0.73±0.27 with p=0.004, pre-chronic kidney disease was -2.64±0.82 with p=0.002, UPCR was -0.02±0.01 g/g with p<0.001, albumin (< -0.2 or > 0.6 g/dl) was 0.97±0.26 with p<0.001, phosphate was -0.76±0.16 with p<0.001, hemoglobin was 0.62±0.05 with p<0.001, and baseline UPCR was -1.57±0.12 with p<0.001. Conclusion: The present study helps in the patient-based evidence in supporting the assessment of proteinuria as a therapeutic target in subjects having advanced chronic kidney disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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