| Autor: |
Javed, Ghazala, Kuna, Lahari, Thulasamma, Seelamneni, Pallapolu, Priyanka, Kazmi, Munawwar Hussain, Chakraborty, Alokananda, Khan, Asim Ali |
| Zdroj: |
Biochemical & Cellular Archives; Apr2023, Vol. 23 Issue 1, p137-142, 6p |
| Abstrakt: |
Hypertension is predominant condition throughout the world. In Unani (Greek Medicine) hypertension is associated with the Damwi (Sanguine) Temperament. Oxidative stress is implicated in pathogenesis of the hypertension. Hence, GSTT1, GSTM1 and eNOS gene polymorphisms and antioxidant activity were examined in Hypertensive patients’ and healthy controls with Damwi temperament. The eNOS genotyping was done by PCR and RFLP method whereas GST-M1 and GST-T1 genotyping were analyzed by multiplex PCR. In serum samples oxidants and antioxidants were measured by ELISA in 200 Sanguine subjects. The GT genotype of eNOS, GSTM1 and GSTT1 null genotype frequency was found to be high in hypertensive patients (21%,36%,28%) compared to control samples GT (13%, 10%, 04%), respectively. GR, GST and MDA are significantly in correlation with each other. The results of the study indicate reduced antioxidant activity and increased oxidative stress in hypertensive patients with significantly high GSTM1, GSTT1 null genotypes and serum glutathione transferase. Therefore, balancing of antioxidants could be useful in the management of essential hypertension. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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