Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and endometrial cancer risk: a multicentric case–control study.
| Autor: | Esposito, Giovanna, Turati, Federica, Serraino, Diego, Crispo, Anna, Negri, Eva, Parazzini, Fabio, La Vecchia, Carlo |
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| Předmět: |
RESEARCH
LIFESTYLES CONFIDENCE intervals FOOD consumption CASE-control method DIET RISK assessment ENDOWMENT of research MEDICAL protocols PHYSICAL activity ENDOMETRIAL tumors DESCRIPTIVE statistics SOCIODEMOGRAPHIC factors BODY mass index LOGISTIC regression analysis DATA analysis software ODDS ratio MEDICAL research DISEASE risk factors |
| Zdroj: | British Journal of Nutrition; 6/28/2023, Vol. 129 Issue 12, p2133-2141, 9p |
| Abstrakt: | The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) published evidence-based recommendations for cancer prevention focusing on body weight, physical activity, and diet. Our aim is to evaluate whether adherence to the WCRF/AICR recommendations could reduce endometrial cancer risk. We used data from a multicentric, Italian hospital-based case–control study (1992–2006) including 454 endometrial cancer cases and 908 age-matched controls. Adherence to the WCRF/AICR recommendations was measured using a score (range: 0–7) based on seven components: body mass index (BMI), physical activity and five dietary items; higher scores indicated higher adherence. Odds ratios (OR) were estimated by multiple (adjusted) conditional logistic regression models including terms for major confounders and energy intake. Adherence to the WCRF/AICR recommendations was inversely related to endometrial cancer risk (OR = 0·42, 95 % confidence interval (CI) 0·30, 0·61 for the highest compared with the lowest score quartile), with a significant trend of decreasing risk with increasing adherence. An inverse association was also observed for a score including only dietary recommendations (OR = 0·67, 95 % CI 0·46, 0·96 for the highest compared with the lowest score tertile). In stratified analyses, the association was stronger among women with a normal weight, those who were older, and consequently those in post-menopause, and those with ≥ 2 children. In conclusion, high adherence to the WCRF/AICR recommendations has a favourable role in endometrial cancer risk, which is not fully explained by body weight. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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