Possible new routes to 3′-thionucleotides and their polymers of pharmacological and prebiotic interest.

Autor:	Nagyvary, Joseph
Předmět:	SUBSTITUTION reactions ORIGIN of life CHEMISTS REACTION forces POLYMERS NUCLEOPHILIC reactions
Zdroj:	Structural Chemistry; Jun2023, Vol. 34 Issue 3, p769-775, 7p
Abstrakt:	Reaching back to his discontinued research done some 50 years ago, a retired chemist proposes novel synthetic routes to 3′-thiocytidylates and their polymers. The driving force of these reactions is based on the superior nucleophilicity of the thiophosphate anion coupled with charge interactions in facilitating displacement reactions on anhydrocytidine moieties. The products of these reactions could be of biochemical and pharmacological interest. If the polymerization reaction would indeed take place in water as suggested, it might fill a gap in prebiotic/origin of life chemistry. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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