Diet quality, food intake and incident adult-onset asthma: a Lifelines Cohort Study.

Autor:	Visser, Edith, de Jong, Kim, Pepels, Janneke J. S., Kerstjens, Huib A. M., ten Brinke, Anneke, van Zutphen, Tim
Předmět:	ASTHMA risk factors RELATIVE medical risk ASTHMA CONFIDENCE intervals FOOD consumption DIET DISEASE incidence REGRESSION analysis RESEARCH funding FOOD quality BODY mass index FOOD chemistry LONGITUDINAL method ADULTS
Zdroj:	European Journal of Nutrition; Jun2023, Vol. 62 Issue 4, p1635-1645, 11p, 1 Diagram, 2 Charts, 2 Graphs
Abstrakt:	Purpose: Dietary factors have been suggested as drivers of the rising prevalence of adult-onset asthma, but evidence is inconclusive, possibly due to the complex interrelation with obesity. We aim to explore the relation of diet quality and food intake with incident adult-onset asthma in normal weight and overweight adults of the prospective population-based Lifelines Cohort Study. Methods: Incident adult-onset asthma was defined as self-reported asthma at ± 4-year follow-up, in adults free of airway disease at baseline. Diet quality scores and food group intake were assessed at baseline. Log-binomial regression analyses were used to estimate adjusted relative risks (RR) between dietary intake (per portion) and incident adult-onset asthma, in categories of BMI (cutoff: 25 kg/m2). Results: 477 incident asthma cases (75% female, 62% overweight) and 34,698 controls (60% female, 53% overweight) were identified. Diet quality—assessed by the Lifelines Diet Score and Mediterranean Diet Score—was not associated with incident adult-onset asthma in the two BMI groups. Although the dietary intake of several food groups differed between cases and controls, after adjustment for confounders only few remained associated with adult-onset asthma, including red and processed meat (RR: 0.93 per 15 g intake; 95% CI 0.86–0.99) in the normal weight group and intake of cheese (RR 1.09 per 20 g intake; 95% CI 1.00–1.17) and vegetables (RR 1.10 per 50 g intake; 95% CI 1.00–1.21) in the overweight group. Conclusion: The results of this study question the role of food as a 'simple' predictor of adult-onset asthma and call for an integrative approach, including a range of modifiable lifestyle factors and further asthma phenotyping. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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