The dose–response of direct oral anticoagulants is non‐linear at plasma levels below 100 ng/ml.

Autor:	Metze, Michael, Siegemund, Annelie, Siegemund, Thomas, Klöter, Tristan, Stöbe, Stephan, Laufs, Ulrich, Petros, Sirak, Pfrepper, Christian
Předmět:	ANTICOAGULANTS THROMBOEMBOLISM DOSE-effect relationship in pharmacology BLOOD coagulation factors DATA analysis software THROMBIN MICROBIAL sensitivity tests
Zdroj:	International Journal of Laboratory Hematology; Jun2023, Vol. 45 Issue 3, pe60-e63, 4p
Abstrakt:	The article focuses on the dose-response relationship of direct oral anticoagulants (DOACs) at plasma levels below 100 nanograms (ng) per milliliter (mL). It describes a study that investigated the thrombin generation (TG) profiles of different DOACs at various plasma drug levels and highlights the non-linear dose-response relationship, with higher inhibition of thrombin generation observed at lower plasma levels.
Databáze:	Complementary Index
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