Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice.

Autor:	Azabdaftari, Aline, Jones, Kelsey D. J., Kammermeier, Jochen, Uhlig, Holm H.
Předmět:	INDIVIDUALIZED medicine CLINICAL medicine INFLAMMATORY bowel diseases IMMUNOLOGICAL tolerance GENETIC disorders
Zdroj:	Human Genetics; May2023, Vol. 142 Issue 5, p599-611, 13p
Abstrakt:	Over 100 genes are associated with monogenic forms of inflammatory bowel disease (IBD). These genes affect the epithelial barrier function, innate and adaptive immunity in the intestine, and immune tolerance. We provide an overview of newly discovered monogenic IBD genes and illustrate how a recently proposed taxonomy model can integrate phenotypes and shared pathways. We discuss how functional understanding of genetic disorders and clinical genomics supports personalised medicine for patients with monogenic IBD. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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