Insulin‐like growth factor 1: A new prime mover in the pathogenesis of vitiligo.

Autor:	EL‐Komy, Mohammed Hussein Medhat, Sayed, Khadiga S., Mostafa, Wedad Z., Shaker, Olfat, Nasser, Nada, Hassan, Mohammed
Předmět:	VITILIGO SOMATOMEDIN C SOMATOTROPIN NUCLEAR factor E2 related factor
Zdroj:	Australasian Journal of Dermatology; May2023, Vol. 64 Issue 2, pe188-e191, 4p, 1 Graph
Abstrakt:	Keywords: hydrogen peroxide (H2O2); insulin-like growth factor-1; melanocyte; reactive oxygen species (ROS) EN hydrogen peroxide (H2O2) insulin-like growth factor-1 melanocyte reactive oxygen species (ROS) e188 e191 4 05/12/23 20230501 NES 230501 Insulin-like growth factor 1 (IGF-1) has been rising as a putative player in the multifactorial complex pathogenesis of vitiligo.[1] Although the studies culminating in this status are not many, clearly, they are highly supportive. Limitations of the current study were not assessing the levels of IGF-1 in perilesional skin and non-affected skin and not correlating levels of IGF-1 with markers of oxidative stress. The finding, in the present work, that serum IGF-1 is highly sensitive as a marker in vitiligo diagnosis, surpassing skin IGF-1 sensitivity, may further support the systemic nature of the disease (Figure 3). [Extracted from the article]
Databáze:	Complementary Index
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