| Abstrakt: |
Background Tension-type headache (TTH) is becoming a global health problem nowadays. Abnormalities of the peripheral and central nociceptive systems combined with environmental, emotional, and genetic factors play a key role in the pathophysiology of TTH. Thus, it is important to identify peripheral nociceptive sources to prevent central sensitization in patients with episodic TTH and reduce central sensitization in chronic TTH. Purpose: To analyze the levels of inducible Nitric Oxide Synthase (iNOS), CXCL1, and pericranial tenderness in patients with TTH. Methods This is a cross-sectional study on TTH patients in Neurology Polyclinic at RSUP Dr. M. Djamil Padang between January 1st and June 30th, 2021. Examination of Total Tenderness Score (TTS) was done manually. Examination serum levels of iNOS and CXCL1 using the ELISA method. The correlation between iNOS, CXCL1 serum levels, and TTS was performed by Spearman's test. P-value <0.05 was considered statistically significant. Results There were 33 patients with TTH who met the inclusion criteria. Most of the subjects were women (81.81%), with a mean age of 29.61 years (SD±5.15). The mean number of TTS scores was 24.55 (SD±8.58). The median number of iNOS serum levels was 3.26 ng/ml. The median number of CXCL1 serum levels was 222.65 ng/ml. There was a moderate positive correlation between iNOS serum levels and TTS values (p = 0.010; r = 0.444). Also, there was a moderate positive correlation between CXCL1 levels and TTS values (p = 0.039; r = 0.361). Conclusions There was a moderate positive correlation between iNOS, CXCL1 serum levels, and pericranial tenderness in TTH patients. [ABSTRACT FROM AUTHOR] |
