| Autor: |
Douglas, Ellen, Hodgson, Kate A., Olsen, Joy E., Manley, Brett J., Roberts, Calum T., Josev, Elisha, Anderson, Peter J., Doyle, Lex W., Davis, Peter G., Cheong, Jeanie L. Y., Boland, Rosemarie, Burnett, Alice, Charlton, Margaret, Clark, Marissa, Davis, Noni, Duff, Julianne, Hickey, Leah, Johnston, Emily, Lee, Katherine, Mainzer, Rheanna |
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| Zdroj: |
Acta Paediatrica; Jun2023, Vol. 112 Issue 6, p1226-1232, 7p |
| Abstrakt: |
Aim: Systemic postnatal corticosteroids are used to treat or prevent bronchopulmonary dysplasia (BPD) in extremely preterm (EP) or extremely low birth weight (ELBW) infants but are associated with long‐term harm. We aimed to assess the relationship between cumulative postnatal corticosteroid dose and neurodevelopmental outcomes. Methods: Longitudinal cohort study of all EP/ELBW livebirths in Victoria, Australia 2016–2017. Perinatal data were collected prospectively. Neurodevelopmental assessment was performed at 2 years' corrected age. Linear and logistic regression were used to determine relationships between cumulative corticosteroid dose and neurodevelopment, adjusted for gestational age, birth weight, sex and major intraventricular haemorrhage. Results: Seventy‐six EP/ELBW infants received postnatal corticosteroids to treat or prevent BPD, 62/65 survivors were seen at 2 years. Median (IQR) cumulative postnatal corticosteroid dose was 1.36 (0.92–3.45) mg/kg dexamethasone equivalent. Higher cumulative corticosteroid dose was associated with increased odds of cerebral palsy, adjusted OR (95% CI) 1.47 (1.04, 2.07). Higher cumulative corticosteroid dose was also associated with lower cognitive and motor developmental scores, however, this weakened after adjustment for confounding variables: cognitive composite score adjusted coefficient (95% CI) −1.3 (−2.7, 0.1) and motor composite score adjusted coefficient (95% CI) −1.3 (−2.8, 0.2). Conclusion: Higher cumulative postnatal corticosteroid dose in EP/ELBW infants is associated with increased odds of cerebral palsy at 2 years' corrected age. Adequately powered studies are needed to assess the independent effects of cumulative steroid dose on neurodevelopmental outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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