| Autor: |
Galisova, Andrea, Bar-Shir, Amnon |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/7/2023, Vol. 59 Issue 37, p5502-5513, 12p |
| Abstrakt: |
Fluorine-containing materials have enriched the field of molecular and cellular MRI with unambiguous and quantitative detection capabilities. The background-free "hot-spot" display and the large range of chemical shifts of the broad palette of 19F-formulations are now used for a variety of applications. The common features of these formulations are: (i) they are based on organic molecular backbones (i.e., organofluorines); and (ii) their 19F-MRI detectability relies on a well-defined and clearly observed 19F-MR signal. During the last few years, our lab aimed to expand the 19F-MR toolbox with new capabilities that were, thus far, not used in molecular and cellular 19F-MRI. This Feature Article summarizes our developments and implementations in the field of 19F-MRI emphasizing (i) the introduction of ultrasmall inorganic fluoride-based nanocrystals (nanofluorides) as nano-sized (<10 nm) agents for 19F-MRI, and (ii) the use of Chemical Exchange Saturation Transfer (CEST) in the 19F-MRI framework to indirectly amplify 19F-MR signals of otherwise-undetected fluorinated entities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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