| Autor: |
Rosenbaum, Daniel M., Grotta, James C., Yatsu, Frank M., Picone, Carmela M., Pettigrew, L. Creed, Bratina, Patti, Zabramski, Joseph, Spetzler, Robert, Lopez, Lynda, Marler, John, Ellis, David |
| Předmět: |
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| Zdroj: |
Angiology; Nov1990 Part 2, Vol. 41, p1017-1022, 6p |
| Abstrakt: |
The author performed a pilot study of nicardipine (NC), a Ca + + channel blocker, to study its dosing, toxicity, and possible efficacy for hemispheric cerebral infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability of proceeding with a multi-centered controlled trial. NC was administered IV (3 to 7 mg/ hr) X 72 hours by titrating dose to mean arterial blood pressure (MABP not <10% of baseline), then orally X 30 days. Forty-three patients have been entered; mean age 63 (range 34- 89), 25 male and 18 female. Only 3 had CT evidence of infarct on entry. Results have shown improvement in a 100-point (pt) graded exam (40 pts at entry, 68 pts at 3 months). Of 20 patients completing 3 months' evaluation, 17 improved and none worsened. Sixteen out of 20 were at home and 8 had minimal or no impairment. Mean Barthel's index was 72. Mean maximal serum NC level was 75 ng/mL. MABP decreased from 103 (entry) to 83 (72 hours). A larger controlled study is warranted to determine the efficacy of NC for acute cerebral infarct. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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