| Autor: |
RAPTI, VASILIKI, LIVANOU, MARIA-EFFROSYNI, KOLLIAS, ANASTASIOS, KOUTOURATSAS, TILEMACHOS, SAVRANAKIS, ORESTIS, SAKKA, VISSARIA, NITSOTOLIS, THOMAS, KAKALOU, ELENI, ATHANASIOU, KALOMOIRA, SYRIGOS, KONSTANTINOS N., POULAKOU, GARYFALLIA |
| Předmět: |
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| Zdroj: |
In Vivo; May/Jun2023, Vol. 37 Issue 3, p1312-1317, 6p |
| Abstrakt: |
Background/Aim: Immunomodulatory therapy with Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 receptor-alpha, has been endorsed by the World Health Organization and other major regulatory bodies, as part of the standard-of-care therapy for severe or critical COVID-19 cases despite discordant trial outcomes. The aim of the present study was to report the experience of our center regarding TCZ routine use in severely ill COVID-19 patients who were hospitalized during the third pandemic wave in Greece. Patients and Methods: From March 2021 to December 2021, we retrospectively analyzed COVID-19 patients with radiological findings of pneumonia and signs of rapid respiratory deterioration that were treated with TCZ. The primary outcome included the risk of intubation or/and death in TCZ-treated patients compared to matched controls. Results: TCZ administration was neither predictive of intubation and/or death [OR=17.5 (95% CI=0.47-652.2; p=0.12)] or associated with fewer events (p=0.92) in multivariate analysis. Conclusion: Our single-center real-life experience is in line with recently published research, revealing no benefit from TCZ routine use in severely or critically ill patients with COVID-19. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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