| Autor: |
Yılmaz, Mustafa Cem, Erkılıç, Ezgi, Karakelle, Nursen, Akçaalan, Yasemin, Göğüş, Nermin, Menekşe, Ebru, Dumlu, Gürkan, Öğüt, Betül, Dinçel, Aylin Sepici |
| Předmět: |
|
| Zdroj: |
Journal of Anesthesia / Anestezi Dergisi (JARSS); 2023 Special Issue, Vol. 31, p206-214, 9p |
| Abstrakt: |
Background: Preoperative fasting is a traditional method used to avoid pulmonary aspiration and related complications. However, with the introduction of enhanced recover after surgery (ERAS) protocols in recent years, preoperative fasting periods have started to decrease. Short periods of fasting have been shown to reduce insulin resistance, acute phase response and oxidative stress in the perioperative period. Ischemia reperfusion injury has an important place in the etiology of acute kidney injury. In our study, we aimed to observe the effect of preoperative short fasting periods on renal ischemia reperfusion injury. Materials and Methods: 21 wistar albino rats in 3 groups were included in the study. Rats were randomized as sham A group fasted for 12 hours preoperatively, group B fasted for 12 hours preoperatively, group C for 2 hours preoperatively. Blood samples were taken for preoperative baseline biochemical values. After abdominal laparotomy, rats in groups B and C, renal ischemia applied by clamping left renal pedicle 20 min. Then 20 minutes reperfusion was allowed. After laparotomy in group A, after reperfusion in groups B and C, left and right nephrectomy was performed and samples were stored for histopathological examination. After blood samples were taken to measure postoperative biochemical values, the rats were sacrificed. Results: In the histopathological examination, proximal tubular epithelium brush-border loss, apoptosis and tubular cast formation were examined. In terms of apoptosis, the score was significantly higher in the left kidney with ischemia in group B compared to the right kidney (p = 0.008). A similar increase was not observed in other groups. In terms of tubular cast formation, statistically significant increases were observed for both right and left kidneys in group B (p = 0.015, p = 0.017). There wasn't statistically significant difference between and within the groups in the evaluations made with interleukin-6 and neutrophil gelatinase-associated lipocalin (NGAL) biochemically. Conclusion: In our study, we found that the preoperative short fasting period in rats has a positive effect in the case of mild renal ischemia reperfusion injury. However, we think that many more studies should be done on this subject. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
