| Abstrakt: |
The global epidemic of coronavirus disease 2019 (COVID‐19) endangers more and more people. Many studies on cutaneous manifestations related to COVID‐19 have emerged, but their prevalence has varied widely. The objective of this study was to conduct a meta‐analysis estimating the prevalence of skin manifestations in COVID‐19. Four databases PubMed, Web of Science, CBM, and CNKI were searched, and the results were screened by two reviewers. A random‐effects model was used to evaluate the overall prevalence. Heterogeneity was assessed by I2. Further subgroup analyses were conducted by region, sample size, sex, age, and severity of COVID‐19. A funnel plot and Egger's test were performed to assess publication bias. The pooled prevalence of cutaneous manifestation of 61 089 patients in 33 studies was 5.6% (95% confidence intervals [CI] = 0.040–0.076, I2 = 98.3%). Severity of COVID‐19 was probably the source of heterogeneity. Studies with sample size <200 report higher prevalence estimates (10.2%). The prevalence of detailed types was as follows: maculopapular rash 2%, livedoid lesions 1.4%, petechial lesions 1.1%, urticaria 0.8%, pernio‐like lesions 0.5%, vesicular lesions 0.3%. Petechial lesions and livedoid lesions contain a higher proportion of severe patients than other skin manifestations. The prevalence rates of pernio‐like lesions, urticaria and petechial lesions vary greatly in different regions. [ABSTRACT FROM AUTHOR] |
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