| Autor: |
Falus, A., Merétey, Katalin, Bagdy, D., Diószegi, Marianna, Böhm, Ute, Csák, Éva, Bozsóky, S. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jan1982, Vol. 47 Issue 1, p103-109, 7p |
| Abstrakt: |
The anti-platelet activity of beta-2-microglobulin (β2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. It was established that human anti-β2m autoantibodies and heterologous rabbit anti-β2m antibodies evoke a dose-dependent aggregation of human platelets. Anti-β2m autoantibodies also impaired ADP-induced platelet aggregation. Antibodies with anti-β2m activity could be desorbed from the platelets and lymphocytes of a patient with systemic lupus erythematosus who was not thrombocytopenic. The possibility that such autoantibodies may alter platelet function is considered. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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