Prognostic Significance of Combined Inflammatory Index (CII) in Nodular Lymphocyte Predominant Hodgkin Lymphoma.
| Autor: | Paydas, Semra, Cakar, Merih Kizil, Barista, Ibrahim, Seydaoglu, Gulsah, Pehlivan, Metin, Dogan, Mutlu, Altuntas, Fevzi, Civriz, Sinem, Unal, Ali, Yildiz, Birol, Lacin, Sahin, Ozsan, Hayri, Ulu, Bahar Uncu, Arslan, Onder, Bilgin, Seyda, Ozcan, Muhit, Gullu, Ibrahim, Begendi, Nermin Keni, Baslar, Zafer, Karadurmus, Nuri |
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| Předmět: |
HODGKIN'S disease
RESEARCH STATISTICS RITUXIMAB CONFIDENCE intervals INFLAMMATION MULTIVARIATE analysis AGE distribution LOG-rank test RETROSPECTIVE studies RISK assessment T-test (Statistics) LYMPHOPENIA LEUKOCYTE count SURVIVAL analysis (Biometry) ANEMIA DESCRIPTIVE statistics CHI-squared test KAPLAN-Meier estimator RECEIVER operating characteristic curves PROGRESSION-free survival SENSITIVITY & specificity (Statistics) DATA analysis DATA analysis software ODDS ratio LYMPHOCYTE count PROPORTIONAL hazards models |
| Zdroj: | Eurasian Journal of Medical Investigation; 2023, Vol. 7 Issue 3, p235-245, 11p |
| Abstrakt: | Objectives: Inflammatory indexes are shown to have clinical significance in cancer. We aimed to determine the prognostic significance of a novel scale index as combined inflammatory index (CII) including leukocyte/lymphocyte ratio(LLR) & prognostic nutritional index(PNI) in nodular lymphocyte predominant Hodgkin Lymphoma(NLPHL) comparing them with well-known prognostic factors. Methods: 101 patients were evaluated retrospectively. Cut-offs were 3.9 for LLR and 53.5 for PNI by ROC analyses. A novel scale-index ('combined inflammatory index-CII') was obtained by the combination of LLR and PNI. Results: There was a moderate negative correlation between PNI and LLR (r=-0,66). In univariate analyses, advanced stage, bone marrow infiltration(BMI), B symptoms, lymphocytopenia, hypoalbuminemia, higher LLR(=3.9) and lower PNI(=53.5) were found to be significant prognostic factors. In multivariate analyses, LLR, PNI and CII were found to be independent significant risk factors for PFS while the models were standardized by age, stage, anemia, hypoalbuminemia, B symptoms & bulky disease. Conclusion: Prognostic score examining LLR and PNI besides other clinical parameters showed that patients in high risk group (higher LLR and lower PNI) had shortest PFS. In conclusion, a scoring system combining LLR and PNI is a novel scoring system in NLPHL.Combined inflammatory index-CII can be used as a prognostic factor in NLPHL. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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