Changes in K + Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma.

Autor:	Santos, Benedito M. Dos, Przyborski, Jude M., Garcia, Célia R. S.
Předmět:	APICOMPLEXA PLASMODIUM PHOSPHOLIPASE C LIFE cycles (Biology) TOXOPLASMA PARASITES
Zdroj:	International Journal of Molecular Sciences; Apr2023, Vol. 24 Issue 8, p7276, 11p
Abstrakt:	During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in cytosolic calcium. In the present report, we summarize the information available in the literature regarding the role of potassium ions during parasite development. A deeper understanding of the mechanisms that allow the parasite to cope with ionic potassium changes contributes to our knowledge about the cell cycle of Plasmodium spp. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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